Fig. 3

Analysis of serum metabolomics of DoC patients with different CRS-R scores. A OPLS-DA model based on patients’ serum metabolites for classification of patients with CRS-R scores less than or equal to 7 and patients with CRS-R scores greater than 7; B volcano plot for filtering differential metabolites (VIP value ≥ 1, fold change ≥ 1.5); C heatmap of differential metabolites in the two groups (blue indicate relative lower and red indicate relative higher in the group with higher CRS-R scores); D–F box plots for relative intensities of lysoPC(18:2(9Z,12Z)), D-(+)-cellobiose, and creatine in DoC patients with different CRS-R scores